Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity

Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity

Decoquinate (DQ) is highly effective at killing malaria parasites in vitro; however, it is extremely insoluble in water. In this study, solid dispersion method was used for DQ formulation which created a suitable physical form of DQ in aqueous phase for particle manipulation. Among many polymers and surfactants tested, polyvinylpyrrolidone 10, a polymer, and L- α -phosphatidylcholine or polysor...

Combinative Particle Size Reduction Technologies for the Formulation of Poorly Soluble Drugs

1. Salazar, Jaime; Müller, Rainer H.; Möschwitzer, Jan P., (2009), “Systematic investigationto establish optimal process parameters for a novel particle size reduction method”, AnnualMeeting of the German Pharmaceutical Society (DPhG), Jena/Germany, September 28 –October 1, 2009. Poster presentation, abstract C48, booklet page 45. 2. Salazar, Jaime; Ghanem, Antoine; Müller, Rainer H...

Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs

Poorly water-soluble drugs, such as phenylephrine, offer challenging problems for buccal drug delivery. In order to overcome these problems, particle size reduction (to the nanometer range) and cyclodextrin complexation were investigated for permeability enhancement. The apparent solubility in water and the buccal permeation of the original phenylephrine coarse powder, a phenylephrine-cyclodext...

Pharmaceutical Formulation for Poorly Water Soluble Camptothecin Analogues

Nanosizing of poorly water soluble compounds using rotation/revolution mixer.

In this study, nanoparticles of various poorly water soluble compounds were prepared by wet milling that was carried out using a rotation/revolution mixer and zirconia balls. To be compared with Beads mill, rotation/revolution mixer has superior in very quick process (5 min) and needs very few amounts of zirconia balls (2.4 g) for pulverizing drugs to nanometer range. Phenytoin, indomethacin, n...